San Diego is a city located on the coast of the Western United States in the state of California. San Diego is the second largest city in California and the eighth largest city in the United States. The California Department of Finance's latest figures estimate the city's population at 1,336,865. The city is also the county seat of San Diego County as well as the economic center of the San Diego–Carlsbad–San Marcos metropolitan area. As of 2008, this metropolitan area is the 17th-largest in the United States with a population of 3,146,274 and the 21st-largest metropolitan area in the Americas when including Tijuana, Mexico.
San Diego's economy is largely composed of agriculture, biotechnology/biosciences, computer sciences, electronics manufacturing, defense-related manufacturing, financial and business services, ship-repair and construction, software development, telecommunications, and tourism. The presence of the University of California, San Diego (UCSD) with the affiliated UCSD Medical Center promotes research in biotechnology.
The area of San Diego has long been inhabited by the Kumeyaay indians. The first European to visit the region was Portuguese-born explorer Juan Rodrigues Cabrillo sailing under the Spanish Flag, who sailed his flagship San Salvador from Navidad, New Spain. Cabrillo claimed the bay for the Spanish Empire and named the site San Miguel. In November of 1602, Sebastián Vizcaíno was sent to map the California coast. Arriving on his flagship San Diego, Vizcaíno surveyed the harbor and what are now Mission Bay and Point Loma and named the area for the Catholic Saint Didacus, a Spaniard more commonly known as San Diego. On November 12, 1602, the first Christian religious service of record in Alta California was conducted by Fray Antonio de la Ascensión, a member of Vizcaíno's expedition, to celebrate the feast day of San Diego.
In 1769, Gaspar de Portolà established the Fort Presidio of San Diego overlooking Old Town. Around the same time, Mission San Diego de Alcalá was founded by Franciscan friars under Father Junípero Serra. By 1797, the mission boasted the largest native population in Alta California, with over 1,400 neophytes living in and around the mission proper. After New Spain won its independence from the Spanish Empire in 1823, Mission San Diego de Alcalá's fortunes declined in the 1830s after the decree of secularization was enacted, as was the case with all of the missions under the control of Mexico. In 1847 San Diego was a destination of the 2,000-mile march of the Mormon Battalion which built the city's first courthouse with brick.
After the Battle of San Pasqual, the end of the Mexican-American War, and the gold rush of 1848, San Diego was designated the seat of the newly-established San Diego County and was incorporated as a city in 1850. In the years before World War I, the Industrial Workers of the World labor union conducted a free speech fight in San Diego, arousing a brutal response.
Significant U.S. Naval presence began in 1907 with the establishment of the Navy Coaling Station, which gave further impetus to the development of the town. San Diego hosted two World's Fairs, the Panama-California Exposition in 1915, and the California Pacific International Exposition in 1935. Many of the Spanish/Baroque-style buildings in the city's Balboa Park were built for these expositions, particularly the one in 1915. Intended to be temporary structures, most remained in continuous use until they progressively fell into disrepair. All were eventually rebuilt using castings of the original facades to faithfully retain the architectural style.
After World War II, the military played an increasing role in the local economy, but post-Cold War cutbacks took a heavy toll on the local defense and aerospace industries. The resulting downturn led San Diego leaders to seek to diversify the city's economy, and San Diego has since become a major center of the emerging biotechnology industry. It is also home to telecommunications giant Qualcomm.